A 2019 Government Accountability Agency (GAO) study of “Patient Options for Safe and Effective Disposal of Unused Opioids” noted that prescription size contributes to opioid misuse. “The majority of patients who received prescriptions for opioids often do not use a large portion of the drugs dispensed.”  Unused opioids in the home may be misused by others and present a poisoning danger to children and pets. Other studies have cited the danger of over-prescribing opioid painkillers to treat post-surgical pain and relatively minor illnesses and injuries, such as sprained ankles.

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